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KRAS Mutation Kit

TRUPCR® ALL Panel Kit

The TRUPCR® ALL panel Kit is intended for the qualitative detection of diagnostic and prognostic markers of acute lymphoblastic leukemia (ALL) in peripheral blood samples using real time PCR system. TRUPCR® ALL panel Kit is based on Real time PCR. In real-time PCR, the analysis is based on fluorescent signal generated from the presence of an oligonucleotide probe specific for target DNA sequence. TRUPCR® AML Panel kit is a comprehensive kit which includes complete cDNA chemistry for RNA based transcripts. List of markers detected by TRUPCR® ALL panel Kit.

  • ALL Panel Kit

Key Features:

  • TRUPCR® ALL Panel Kit allows comprehensive detection of most common diagnostic and prognostic markers for ALL.
  • It detects most common variants of transcripts in the fusion genes.
  • The kit offers sensitivity to detect up to 10 copies of fusion transcripts.
  • All the reagents for cDNA chemistry, PCR and real-time PCR are included in the kit.
  • It is compatible with various Real Time& Conventional PCR instruments.
  • Easy-to-use, rapid, reliable, comprehensive and cost-effective tests.

Mutation Variants detected by TRUPCR® ALL Panel Kit

No. GENE VARIENT
1 BCR-ABL1 e13a2 & e14a2 (p210)
e1a2 (p190)
e19a2 (p230)
2 TEL-AML1 BCL2L14-RUNX1
3 E2A-PBX1 TCF3-PBX1
4 MLL-AF4 MLL_AF4_e10-e4
MLL_AF4_e9-e4
MLL_AF4_e9-e5
MLL_AF4_e11-e4
MLL_AF4-e9-e6
5 MLL-AF9 MLL-AF9 _e8-e9
MLL-AF9 _e8-e10
MLL-AF9 _e10-e6
6 MLL-ENL MLL-ENL_e9-e2
MLL-ENL_e10-e2
7 ABL1 Control


Acute lymphoblastic leukemia (ALL) is mainly a disease of childhood that arises from recurrent genetic alterations that block precursor B- and T-cell differentiation and drive aberrant cell proliferation and survival. Due to the advances in the cytogenetic and molecular characterization of the acute leukemias in the past two decades, genetic alterations can now be identified in more than 80% of cases of ALL. These genetic lesions influence the prognosis and therapeutic approach used for treatment of ALLs. Chromosomal translocation is the hallmark of leukaemias and acute lymphoblastic leukaemia (ALL) in particular. DNA damage arises from endogenous and exogenous genotoxic factors and lack of complete fidelity in DNA-repair leads to chromosomal translocations. Chromosomal breakpoints tend to occur at transcriptionally active DNA sites and the fusion gene transcripts generally involve genes which frequently encode cell cycle regulators, transcription factors, signal transduction molecules, receptors or immunoglobulin and TCR molecules. Due to the chromosomal translocations and subsequent expression of fusion gene transcripts, the normal functions of the genes are altered.

Ordering Information:

CAT. NO. PRODUCT CONTENTS
1405 TRUPCR® ALL Panel Kit 24Rxn
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