TRUPCR® HPV 16 & 18 Detection Kit
The TRUPCR® HPV High Risk (E6/E7) Kit is designed for the qualitative detection of DNA of High-Risk Human Papillomavirus (HPV) in clinical samples by using real time PCR. HPV infections are among the most common sexually transmitted infections. Most HPV infections have a benign clinical consequence and are cleared spontaneously. However, persistent HPV infection may result in progression to cervical cancer. More than one hundred different HPV genotypes have been identified, among which over forty infect mucosal and genital epithelia. Genital HPV genotypes are generally classified into high risk (HR) and low risk (LR) groups based on their carcinogenic potential. High-risk HPVs also called oncogenic HPVs, which have been confirmed to cause cancer, includes HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. And some HPVs are possibly carcinogenic to humans, like HPV 26, 53, 66, 70, 73 and 82, that be classified as high-risk or probably high-risk HPVs.
The TRUPCR® HPV High Risk (E6/E7) Kit is an RT-qPCR assay based on oligonucleotide hydrolysis principle which allows higher specificity and sensitivity of E6/E7 region by primer and probes specific for HPV 14 Genotypes (16/18/31/33/35/39/45/51/52/56/58/59/66 and 68) and simultaneous genotyping of 16 and 18.